藥毒所100年度

20 2011 A nnual R eport 表 6. 五種農藥單一或混合處理 Rh B 對大鼠胚胎荷爾蒙干擾作用與發育毒性 Table 6. Summary for the endocrine disrupting activity and developmental toxicity induced by in combination with five pesticides alone and Rh B in rat embryo culture Treatment Aromatase ERα ERβ AR Dev Tox Rhodamine B （ Rh B ） ? + + ? - 17β-Estradiol （ E 2 ） ? + + ? - Testosterone propionate ? - - ? - Prochloraz ? + + ? - Permethrin ? + + ? - Cypermethrin ? + ± ? - Fenitrothion ? + ± ? - Fenvalerate ? + ± ? - Rh B + Prochloraz ? + + ? - Permethrin ? + + ? - Cypermethrin ? + ± ? - Fenitrothion ? + ± ? - Fenvalerate ? + ± ? - Note:-: No effect; +: effect; ± : little effect; ? : It cannot be determined due to the lack of obvious effect of rhodamine B and testosterone propionate, a positive control for aromatase and AR in this test system, respectively; Dev Tox.: developmental toxicity 表 7. 五種農藥單一或混合處理雌素二醇對大鼠胚胎荷爾蒙干擾作用與發育毒性 Table 7. Summary for the endocrine disrupting activity and developmental toxicity induced by in combination with five pesticides alone and E 2 in rat embryo culture Treatment Aromatase ERα ERβ AR Dev Tox Rhodamine B （ Rh B ） ? + + ? - 17β-Estradiol （ E 2 ） ? + + ? - Testosterone propionate ? - - ? - Prochloraz ? + + ? - Permethrin ? + + ? - Cypermethrin ? + ± ? - Fenitrothion ? + ± ? - Fenvalerate ? + ± ? -