臺灣農藥科學第四期電子書

18 臺灣農藥科學 第 4 期 Performance Report on a Commercialized Platform for the Development and Toxicological Study of Natural Pesticides Jin-Yi Chang 1* , Yi-Jing Chuang 1 , Shao-Jung Lo 1 , Wei-Jia Wu 1 , Tzay-Tien Hsieh 1, Wei-Ren Tsai 1 Abstract Chang, J. Y., Chuang, Y. J., Lo, S. J., Wu, W. J., Hsieh, T. T., and Tsai, W. R. 2018. Perfor- mance report on a commercialized platform for the development and toxicological study of natu- ral pesticides. Taiwan Pestic. Sci. 4:1-19. Natural pesticides are considered to be safe to humans, other animals, and the surrounding environment. A multidisciplinary team of research specialists (including area of toxicology, veterinary, and biology) was organized by TACTRI to fill research gaps related to key techniques and to help overcome the legal obstacles to product registration. The overall goal of this work was to establish a commercial platform to collect natural pesticides (explored by District Agricultural Research and Extension Station, universities and colleges), and to prepare toxicological data requirements for registration in order to facilitate technology transfer and product launch. The objectives of the project included: 1. Collect international requirements for the registration of biopesticide products; 2. propose related guidelines for toxicity classification and for the testing of acute toxicity and toxicity in non-target organisms; and 3. conduct the required toxicological studies and prepare study reports. Specifically, 26 natural pesticides were selected for this project, and toxico- logical studies (which included 62 GLP study reports) were completed for 22 of them. Our results revealed that the acute oral toxicity of all 22 tested products fell under the category “slightly to practically non-toxic”; therefore, all these products can be considered safe. Accepted: September 4, 2018. * Corresponding author, E-mail: jinyi@tactri.gov.tw 1 Taiwan Agricultural Chemicals and Toxic Substances Research Institute, Council of Agriculture, Taichung