藥毒所108年報

18 2019 Annual Report 利用危害作用途徑 (AOP) 作用機制原理評估 具潛在風險農藥代謝產物 網 蒐 彙 整 A O P 7 ( 2 , 3 , 7 , 8 - t e t r a c h l o r o d i b e n z o - p - d i o x i n , 4 - hydroxytamoxifen, rosiglitazone , mono- ethylhexyl phthalate , fenofibrate ) 、 AOP 19 (bicalutamide, linuron, nilutamide, v i n c l o z o l i n ) 、 AOP 23 ( p r o c h l o r a z , ketoconazole, 17-trenbolone, fadrozole, b i spheno l A, oc t y l pheno l ) 、 AOP 25 表 6. 法規面於豆科乾豆類作物病害防治推薦前 10 名用藥之女性理論累積多重危害商數 推估結果 Top 10 pesticides MRL (ppm) Theoretical total exposure 1) (mg/kg/day) ADI (mg/kg/day) Theoretical hazard index 2) Profenofos (Top 1) 0.05 0.00000538 0.01 0.000537803 Spinetoram (Top 2) 0.05 0.00000538 0.024 0.000224085 Bifenthrin (Top 3) 0.5 0.00005378 0.01 0.005378034 Fenvalerate (Top 4) 0.1 0.00001076 0.02 0.000537803 Permethrin (Top 5) 0.05 0.00000538 0.05 0.000107561 Azoxystrobin (Top 6) 0.5 0.00005378 0.1 0.000537803 Fluxapyroxad (Top 7) 0.4 0.00004302 0.02 0.002151214 Pyraclostrobin (Top 8) 0.5 0.00005378 0.03 0.001792678 Tridemorph (Top 9) 0.5 0.00005378 0.015 0.003585356 Difenoconazole (Top 10) 3 0.00032268 0.05 0.006453641 Spinetoram Level 2a Hypertrophy 0.000224085 Azoxystrobin 0.000537803 Fluxapyroxad 0.002151214 Pyraclostrobin 0.001792678 Spirotetramat 0.006453641 Theoretical cumulative hazard index 3) CAG 4) Specific toxicity effect 0.01115942 1) Total exposure= MRL (ppm)* ﹝ Dairy food intake(kg/person/day) ﹞ / ﹝ Body weight (kg) ﹞ 2) HI= total exposure/ ADI 3) Cumulative HI ABC … = HI A + HI B + HI C + HI…(A, B and C having a common mode of action) 4) CAG= Common Assessment Groups, which is the pesticides having a common mode of action