藥毒所101年度

壹 試 17 圖 15. 貝芬替與二甲基砷酸鈉對小鼠主要臟器之組織病理變化 (H&E 染色， 100 × ) 。 肝臟 (A) 、腦 (B) 、腎臟 (C) 及腎上腺 (D) 均無明顯組織病理變化。 表 4. 貝芬替對小鼠白血球分類計數之變化 表 5. 甲基砷酸鈉對小鼠白血球分類計數之變化 Data are expressed as mean ± S.D. (n = 5). *Indicates significant difference compared with control group at p < 0.05. Data are expressed as mean ± S.D. (n = 5). *Indicates significant difference compared with control group at p < 0.05. Item/Group D.W. (10 ml/kg) CPA (10 mg/kg) dimethylarsinic acid sodium salt trihydrate (6 mg/kg) dimethylarsinic acid sodium salt trihydrate (12 mg/kg) dimethylarsinic acid sodium salt trihydrate (24 mg/kg) Monocytes 20.92 ± 3.78 28.35 ± 5.32* 20.70 ± 4.35 20.24 ± 2.26 19.56 ± 3.06 Lymphocytes 60.65 ± 0.87 56.73 ± 2.02 65.88 ± 5.01 72.90 ± 5.14 64.14 ± 2.87 Neutrophils 14.38 ± 2.40 16.70 ± 3.68 11.76 ± 1.52 8.13 ± 2.92* 14.12 ± 3.61 Eosinophils 2.32 ± 0.97 2.53 ± 1.82 1.64 ± 0.51 1.34 ± 0.94 1.86 ± 1.28 Basophils 0.00 ± 0.00 0.45 ± 0.07 0.00 ± 0.00 0.10 ± 0.00 0.32 ± 0.00 Item/Group D.W. (10 ml/kg) Corn oil (10 ml/kg) CPA (10 mg/kg) Carbendazim (150 mg/kg) Carbendazim (300 mg/kg) Carbendazim (600 mg/kg) Monocytes 15.50 ± 4.40 18.58 ± 4.91 48.68 ± 2.97* 8.55 ± 1.43* 6.63 ± 0.58* 14.77 ± 4.77 Lymphocytes 66.70 ± 3.69 70.13 ± 2.77 20.05 ± 2.17* 71.73 ± 2.57 76.07 ± 3.07 66.30 ± 3.64 Neutrophils 17.72 ± 5.64 11.43 ± 2.55 25.82 ± 3.48* 15.83 ± 2.07 15.97 ± 3.27 18.90 ± 4.41* Eosinophils 4.10 ± 1.79 2.70 ± 1.51 3.55 ± 0.82 3.90 ± 1.27 1.46 ± 0.89 1.28 ± 0.74 Basophils 0.20 ± 0.00 0.30 ± 0.00 0.00 ± 0.00 0.20 ± 0.00 0.30 ± 0.00 0.60 ± 0.00