藥毒所101年度

壹 試 31 圖 31. 標竿劑量 (BMD) 分析原理。 表 7. 陶斯松 NOAEL 與 BMDL 值之比較 Pesticides Animal NOEL (mg/kg/day) BMDL (mg/kg/day) LOEL(mg/kg/day)/Test system/Endpoint SF RfD (mg/kg/day) Chlorpyrifos Rat, Mice, Dog, Human 1 NA Inhibition of brain ChE activity 100 0.01 Dog NA 0.006 Inhibition of female plasma ChE for 2 years 100 0.00006 Dog NA 0.005 Inhibition of male plasma ChE for 2 years 100 0.00005 Dog NA 0.004 Inhibition of female erythrocyte ChE for 2 years 100 0.00004 Dog NA 0.007 Inhibition of male erythrocyte ChE for 2 years 100 0.00007 Dog NA 0.23 Inhibition of male plasma ChE for 2 years 100 0.0023 Dog NA 0.24 Inhibition of female plasma ChE for 2 years 100 0.0024 Dog NA 0.23 Inhibition of male erythrocyte ChE for 2 years 100 0.0023 Rhesus monkey NA 0.05 Inhibition of erythrocyte ChE for 6 months 100 0.0005 Rhesus monkey NA 0.03 Inhibition of plasma ChE for 6 months 100 0.0003 Rhesus monkey NA 0.085 Inhibition of erythrocyte ChE for 6 months 100 0.00085 Rhesus monkey NA 0.047 Inhibition of plasma ChE for 6 months 100 0.00047