藥毒所93年度

11 Glufosinate 95% TG 4.3 ± 3.1 1.5 ± 0.5 - - - 13.5% SL 77.8 ± 10.5* 17.3 ± 3.3* - +++ - Atrazine 80% TG 86.2 ± 7.6* 68.1 ± 7.2* - +++ - 50% WP 94.6 ± 5.3* 75.3 ± 10.5* - - - 1) The aorta rings were precontracted with 2 µ M phenylepherine before application of herbicides at concentration of 1 mM. 2) Mean ± SD (n=3-4). 3) Degree: -: no effect; +: slight; ++: moderate; +++: complete. ND: not detected. * Significant difference between technical and formulated groups at p <0.05 by Student t -test. 表 13. 農藥賦形劑引起胸主動脈環的血管鬆弛及心肌作用之比較 Table 13. Effect of herbicide-formulated solvents precontracted with phenylepherine in isolated rat aorta rings with intact endothelium and heart Effect on the aorta (%) Effect on the heart Chemical Relaxation Contraction Inhibition Contraction Phenylephrine (PE 2 µ M) - 1.6 ± 0.1 g ND ND Acetylcholine (ACh 5 µ M) 94.2 ± 3.3* - ND ND IPA 99% 7.1 ± 5.8 - - - AES 80% 53.0 ± 10.4* - + - EA 99.7% 83.9 ± 2.5* - +++ - Xylene 10 µ /ml 95.7 ± 0.7* - ++ - 1 µ /ml - 24.5 ± 4.1* - - P-170 10 µ /ml 84.3 ± 7.3* - - +++ 1 µ /ml - 43.8 ± 15.6 +++ - S-100 10 µ /ml 88.7 ± 3.2* - - +++ 1 µ /ml - 49.2 ± 15.2 - - The aorta rings were precontracted with 2 µ M phenylepherine before application of solvents, IPA, AES, ethyl acetate at concentration of 1 mM.. Mean ± SD (n=4). Degree: -: no effect; +: slight; ++: moderate; +++: complete. ND: not detected. * Significant difference between technical and formulated groups at p <0.05 by Student t -test.