臺灣農藥科學第一期

臺灣農藥科學　第

期

附錄一、基準劑量分析方法與步驟

Appendix 1.

Procedure for determining benchmark dose (BMD) level

Introduction

BMDs and BMDLs vs. NOAELs and LOAELs

Biological vs. empirical modeling

Before starting a BMD analysis

Study design

Aspects of data reporting

Selecting studies to be modeled

Selecting endpoints to be modeled

Minimum dataset for calculating a BMD

Combining data for a BMD calculation

Dosimetric adjustments

Decision tree for BMD modeling Selecting the

benchmark response level (BMR) Modeling the

data

See figure below

For quantal data

For continuous data

Selecting the model

Type of endpoint

Experimental design

Constraints

Covariates

Model fitting

Assessing how well the model describes the data Global goodness of fit measures (p values)

Scaled residuals at each dose level

Graphical displays

Improving model fit

Comparing models

Within a family of models: the Akaike Informa-

tion Criterion (AIC)

Other considerations

Calculating confidence limits to get a BMDL

Selecting the model to use for POD computation

Reporting recommendations

Source: This information was summarized from the following website:

dose-bmd-methods

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