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體外微核與動物減量試驗之測試趨勢

203

up-and-down procedure.

29. OECD. 2008. TG 425: acute oral toxicity-

up-and-down procedure.

30. OECD. 2010. TG 429: skin sensitization:

local lymph node assay.

31. OECD. 2010. TG 442A: skin sensitization:

local lymph node assay: DA.

32. OECD. 2010. TG 442B: skin sensitization:

local lymph node assay: BrdU-ELISA.

33. OECD. 2014. TG 487:

in vitro

mammalian

cell micronucleus test.

34. OECD. 2014. TG 473:

in vitro

mammalian

chromosome aberration test.

35. Rispin, A., Farrar, D., Margosches, E.,

Gupta, K., Stizel, K., Carr, G., Greene, M.,

Meyer, W., and McCall, D. 2002. Alterna-

tive methods for the LD50 test: the up and

down procedure for acute oral toxicity.

ILAR J. 43: 233-243.

36. Russell, W. M. S., and Burch, R. L. 1959.

The principles of humane experimental

technique. Methuen, London, UK. 238 pp.

37. USEPA. 1998. OPPTS 870.1100: acute oral

toxicity.

38. USEPA. 2002. OPPTS 870.1100: acute oral

toxicity.

39. USEPA. 2002. AOT425StatPgm program.

40. USEPA. 2003. OPPTS 870.2600: skin sen-

sitization.