203 / 220
體外微核與動物減量試驗之測試趨勢
201
的
Vivo Science GmBH
與
Bayer HealthCare
AG
及英國的
Huntingdon Life Sciences
等採
用，此方法目前更被應用於檢測基因改造
作物
(genetically modified crops)
之表現蛋白
質，分析是否因外來基因之轉殖作用
(trans-
formation)
，引發或增強過敏性反應
(18)
。
本所目前已將基因毒理試驗—體外
哺乳動物細胞微核測試
(OECD 487)
及動物
減量技術口服急毒性—定比劑量致死推
定法
(OECD 425
及
USEPA 870.1100)
與皮
膚過敏性—小鼠局部淋巴結細胞增殖分
析
(OECD 442B)
納入本所優良操作實驗室
(Good Laboratory Practice, GLP)
運作系統，
及取得全國認證基金會
(Taiwan Accredita-
tion Foundation, TAF)
認證，不僅可協助業
界產品在國內外登記所需的必備毒理資料
外，亦可提供相關單位作為安全管理之依
據，符合國際毒理測試發展趨勢及落實
3R
的精神，對提升本國毒理測試技術水準及
動物保護成效助益良多。
謝辭
感謝本組蔡寶隆博士及羅紹榮先生等
分別協助英文修訂及資料收集，謹此致謝。
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