204 / 220
臺灣農藥科學 第
1
期
202
principles and methods. Spring Science +
Business Media, London, UK.
10. ESAC. 2006. ECVAM scientific advisory
committee (ESAC) peer review. Retro-
spective validation of the
in vitro
micro-
nucleus test. Summary and conclusions of
the peer review panel. Available at: http://
ecvam
,jric.it/index.htm11. EFSA. 2011. Guidance on the risk assess-
ment of the application of nanoscience
and nanotechnologies in the food and feed
chain.
12. Fenech, M., Chang, W. P., Kirsch-Volders,
M., Holland, N., Bonassi, S., and Zeiger,
E. 2003. HUman MicronNucleus project.
HUMN project: detailed description of the
scoring criteria for the cytokinesis-block
micronucleus assay using isolated human
lymphocyte cultures. Mutat. Res. 534: 65-75.
13. ICH. 2012. S2(R1) genotoxicity testing
and data interpretation for pharmaceu-
ticals intended for human use. U.S. Food
and Drug Administration, Silver Spring,
MD, USA. 35 pp.
14. ILSI Health and Environmental Sciences
Institute. 2012. Project committee on the
relevance and follow-up of positive results
in
in vitro
genetic toxicity (IVGT) testing.
Improving existing assays workgroup.
15. ISO/TR 13121:2011. Nanotechnologies --
nanomaterial risk evaluation.
16. ICCVAM. 2010. Test Method Protocol No.
10-7552: 2-Bromodeoxyuridine-ELISA
Test Method (LLNA: BrdU-ELISA).
17. Joshua, M. B. 2007. Contact Dermatitis,
Allergic. Department of Dermatology,
Louisiana State University Health Sciences
Center School of Medicine.
18. Ladics, G. S., Fry, J., Goodman, R., Herou-
et-Guicheney, C., Hoffmann-Sommergr-
uber, K., Madsen, C. B., Penninks, A., Po-
més, A., Roggen, E. L., Smit, J., and Wal, J.
M. 2014. Allergic sensitization: screening
methods. Clin. Transl. Allergy. 4: 13.
19. Nesslany, F., and Marzin, D. 1999. A mi-
cromethod for the
in vitro
micronucleus
assay. Mutagenesis 14: 403-410.
20. OECD. 1987. TG 401: acute oral toxicity.
21. OECD. 1992. TG 420: acute oral toxicity-
fixed dose method.
22. OECD. 1996. TG 423: acute oral toxicity-
acute toxic class method.
23. OECD. 1998. TG 425: acute oral toxicity-
up-and-down procedure.
24. OECD. 2001. TG 420: acute oral toxicity-
fixed dose method.
25. OECD. 2001. TG 423: acute oral toxicity-
acute toxic class method.
26. OECD. 2001. TG 425: acute oral toxicity-
up-and-down procedure.
27. OECD. 2001. Acute oral toxicity statistical
programme (AOT 425 StatPgm). Version:
1.0.
28. OECD. 2006. TG 425: acute oral toxicity-